Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases characterized by inflammation and damage to small blood vessels. This inflammation is typically caused by ANCAs, self-reactive antibodies that bind to certain cells of the immune system — called neutrophils — and overly activate them. . Researchers believe that a combination of. The ICD-10-CM code I77.6 might also be used to specify conditions or terms like antineutrophil cytoplasmic antibody positive vasculitis, aortitis, aortopulmonary window, arteriolitis, arteritis, chronic peri-aortitis, etc
ANCA vasculitis has an associated autoimmune response that produces ANCAs that induce distinct pathologic lesions. Pauci-immune necrotizing and crescentic GN is a frequent component of ANCA vasculitis. ANCA vasculitis is associated with ANCA specific for myeloperoxidase (MPO-ANCA) or proteinase 3 (PR3-ANCA). A diagnosis of ANCA vasculitis should always specify the serotype as MPO-ANCA positive. A positive C-ANCA immunofluorescence test or a strongly positive PR3-ANCA or MPO-ANCA ELISA test result is highly suspicious for the diagnosis of ANCA-associated vasculitis. Provided that a patient has clinical features of vasculitis, the positive ANCA test helps to confirm the diagnosis along with tissue biopsy results
An ANCA test is most often used to find out if you have a type of autoimmune vasculitis. There are different types of this disorder. They all cause inflammation and swelling of blood vessels, but each type affects different blood vessels and parts of the body. Types of autoimmune vasculitis include The ANCA‐positive rate is much higher in patients with type 1 diabetes mellitus than in healthy individuals. Levamisole, which is a common adulterant of cocaine, can cause an ANCA positive vasculitis. The presence or absence of ANCA cannot indicate presence or absence of disease and results are correlated with clinical features
ANCA - associated systemic vasculitis a subgroup of small vessel vasculitis in which there are circulating antineutrophil cytoplasmic autoantibodies ( ANCA ), including microscopic polyangiitis, Wegener granulomatosis, and some types of Churg - Strauss syndrome . Medical dictionary. 2011. Vascoray. Churg-Strauss vasculitis Of the 237 included MPO and/or PR3 ANCA positive patients, 57% was men with a mean age of 57 ± 19 years. ANCA was PR3 positive in 51% versus MPO positive in 49%. The median follow-up was 5.8 (percentiles 2.7-9.4) years and the median time between the request of the first positive ANCA titre and the diagnosis AAV was 15 days (9.0-36.0) The ICD-10-CM code M31.7 might also be used to specify conditions or terms like microscopic polyarteritis nodosa, microscopic polyarteritis nodosa with multi-organ involvement, microscopic polyarteritis nodosa with single organ involvement, necrosis of artery, polyarteritis nodosa, primary necrotizing systemic vasculitis, etc
Microscopic polyangiitis is the most common ANCA-associated small-vessel vasculitis, and is characterized by the presence of ANCA and few or no immune deposits in the involved vessels.1, 3, 7, 9. Vasculitis ICD-10-CM Alphabetical Index. Vasculitis. The ICD-10-CM Alphabetical Index is designed to allow medical coders to look up various medical terms and connect them with the appropriate ICD codes. There are 11 terms under the parent term 'Vasculitis' in the ICD-10-CM Alphabetical Index For example, ICD-10 classifies vasculitis limited to skin with skin conditions (under L), and necrotizing vasculopathies (corresponding to systemic vasculitis) with musculoskeletal system and connective tissue conditions (under M). Arteritis/phlebitis on their own are classified with circulatory conditions (under I) Autoimmune Disease-Anti-Neutrophil Cytoplasmic Autoantibody (ANCA) Vasculitis is an autoimmune disease that results in vascular tissue inflammation and systemic vasculitis.Antibodies-Autoimmune response by the body is triggered by autoantibodies.Antibodies react against the antigen present in the wall of neutrophils granulocytes and blood vessels.
Short description: Arteritis NOS. ICD-9-CM 447.6 is a billable medical code that can be used to indicate a diagnosis on a reimbursement claim, however, 447.6 should only be used for claims with a date of service on or before September 30, 2015. For claims with a date of service on or after October 1, 2015, use an equivalent ICD-10-CM code (or. ANCA associated vasculitis (AAV) is an umbrella term for a group of multi-system autoimmune small vessel vasculitides that can present at any age and affect 20-25 people per million per year in Europe. 1 A typical GP practice with 8000 patients can expect to see one new case approximately every five years P-Anca Blood Test Results Fully Explained. The P-ANCA blood test is used to determine if there is the presence of perinuclear anti-neutrophil cytoplasmic antibodies present within the blood. This simple test uses a stain to determine their presence because the antibodies offer a positive charge at a pH of 7. These antibodies will form against.
AHA Coding Clinic ® for ICD-10-CM and ICD-10-PCS - 2021 Issue 1; Ask the Editor Anti-Neutrophil Cytoplasmic Autoantibody Vasculitis and Nephritic Syndrome. What is the appropriate diagnosis code assignment for anti-neutrophil cytoplasmic autoantibody (ANCA) vasculitis with nephritic syndrome?. Name: Antineutrophil cytoplasmic antibody positive vasculitis See more descriptions. - Antineutrophil cytoplasmic antibody positive vasculitis (disorder) - Antineutrophil cytoplasmic antibody positive vasculitis. - Antineutrophil cytoplasmic antibody (ANCA) positive vasculitis. Hide descriptions. Concept ID: 722191003. Read Codes: ICD-10 Codes. ICD-10-CM Code. I67.7. Billable codes are sufficient justification for admission to an acute care hospital when used a principal diagnosis. I67.7 is a billable ICD code used to specify a diagnosis of cerebral arteritis, not elsewhere classified. A 'billable code' is detailed enough to be used to specify a medical diagnosis Acute on chronic renal failure 2 2 ANCA vasculitis ICD 10 code. Pulmonary-renal syndrome refers to patients with DAH (or pathologic pulmonary purpura on physical examination implies a small-vessel, cutaneous vasculitis ( 10).. The ANCA-associated vasculitides, WG, CSS, and MPA, are grouped. . The syndrome is characterized by a triad of (1. . based on ICD-10 codes.
This revision is due to the Annual ICD-10 Code Update and becomes effective 10/1/16. Provider Education/Guidance; Revisions Due To ICD-10-CM Code Changes; 07/08/2016 R8 Under ICD-10 Codes that Support Medical Necessity added ICD-10 codes N04.0, N04.1, N04.2, and N05.2 ANCA positivity is less frequently seen than in WG, with a positive P-ANCA (or anti-MPO) seen in 35 to 75% of patients with active disease . A positive C-ANCA has been described in up to 10% of patients. Pathologically, a necrotizing, small-vessel vasculitis and an eosinophil-rich cellular infiltrate with necrotizing granulomas are seen (45, 46) Anti-neutrophil cytoplasmic autoantibody (ANCA) associated vasculitis (AAV) is a group of life-threatening autoimmune diseases affecting mainly small-to-medium vessels , with a poor prognosis if left untreated [2,3,4,5,6,7,8].According to the 2012 classification of the Chapel Hill Consensus Conference (CHCC) , the phenotypes include four clinical syndromes, namely, granulomatosis with.
The diagnosis of systemic vasculitis is a challenge because of the heterogeneity of clinical manifestations. The aim of this study is to analyze the diagnostic delay in systemic vasculitis, the total costs during the first year of care, and how the diagnostic delay affects the costs in a tertiary health care facility. Patients with a new diagnosis of systemic vasculitis between 2010 and 2018. The therapeutic agents associated with ANCA + vasculitis have been listed AAV but may also have a positive ANCA test by of Diseases 10th Revision (ICD-10) data, are. The cytoplasmic pattern, or c-ANCA, is both sensitive and specific for Wegener granulomatosis. The perinuclear pattern, or p-ANCA, is associated with PAN, microscopic polyangiitis, relapsing polychondritis, and renal vasculitis. All positive ANCA tests should be confirmed by testing for antibodies to proteinase-3 (PR3) and/or myeloperoxidase (MPO) Other forms of ANCA-associated vasculitis include eosinophilic granulomatosis with polyangiitis (EGPA) and granulomatosis with polyangiitis (GPA). People with these types of vasculitis often test positive for ANCA, although the test is not conclusive. MPA is a serious but treatable disease vasculitis (e.g., Takayasu arteritis, giant cell arteritis), medium vessel vasculitis (e.g., polyarteritis nodosa, Kawasaki disease), and immune complex small vessel vasculitis (SVV) (e.g., rheumatoid vasculitis, sarcoid vasculitis, and others) (relevant ICD-10 coding in Appendix 2), from which, 6844 patients were excluded
Serum antiprotease 3-ANCA (c-ANCA) is positive in 75 to 90 percent, although 20 percent may have positive p-ANCA Open lung biopsy is the most definitive diagnostic test. Sinus biopsy is diagnostic in only 30 percent of cases because inflammatory findings are often nonspecific and renal biopsy is also relatively nonspecific 24) Search Page 2/15: anca vasculitis. Icd10data.com DA: 17 PA: 7 MOZ Rank: 24. ICD-10-CM Diagnosis Code M05.27 Rheumatoid vasculitis with rheumatoid arthritis of ankle and foot Rheumatoid vasculitis w rheumatoid arthritis of ank/ft; Rheumatoid vasculitis with rheumatoid arthritis, tarsus, metatarsus and phalanges ICD-10-CM Diagnosis Code M05.271 [convert to ICD-9-CM . Typically ANCA positive (about 10% of cases are ANCA negative) ICD-10: ANCA positive vasculitis I77.6 Microscopic polyangiitis M31.7 Wegener's M30.1, M31.30, M31.31 Autoimmune hemolytic anemia (AIHA) 1. Diagnosis of autoimmune hemolytic anemia (including AIHA following allogenic bone marrow transplantation), AND 2. If request is for Rituxan or Truxima: Intolerable side effect with the preferred rituxima
ANCA-positive patients reported increased occupational dust exposure vs. controls (OR 2.6, 95% CI 1.3, 5.3). Exposure to silica was associated with ANCA-positivity (OR 3.4, 95% CI 1.1, 9.9), in a dose-dependent manner, particularly with regards to intensity of exposure. No difference in ANCA serotype found The anti-MPO-ANCA EIA is useful for confirming positive ANCA results by IFA, particularly with the P-ANCA pattern. Presence of anti-MPO antibodies is highly specific for idiopathic and vasculitis-associated crescentic glomerulonephritis, classic polyarteritis nodosa, Churg-Strauss syndrome, and polyangiitis overlap syndrome without renal. ICD-10: ANCA positive vasculitis I77.6 Microscopic polyangiitis M31.7 Wegener's M30.1, M31.30, M31.31 Autoimmune hemolytic anemia (AIHA) 1. Diagnosis of autoimmune hemolytic anemia (including AIHA following allogenic bone marrow transplantation), AND 2. If request is for Rituxan: Intolerable side effect with the preferred rituximab products. The disease is associated with the presence of serum ANCA in 80% to 90% of cases, most often p-(myeloperoxidase or MPO)-ANCA. 298-300 Some patients eventually do develop full-fledged vasculitis, such as Wegener's granulomatosis, months to years after clinical presentation. 301 Cases can be associated with the use of drugs, including. Vasculitis, ANCA-associated (AAV)for any of the following conditions Microscopic polyangiitis- when creatinine is 5.7 mg/dl or greater; Granulomatosis with polyangiitis- when creatinine is 5.7 mg/dl or greater; Renal- limited vasculitis- when creatinine is 5.7 mg/dl or greater; Voltage-gated potassium channel (VGKC) antibody related disease
Vasculitis means inflammation of the blood vessels. Inflammation is your immune system's natural response to injury or infection. It causes swelling and can help the body deal with invading germs. But in vasculitis, for some reason the immune system attacks healthy blood vessels, causing them to become swollen and narrow.. To achieve overall treatment p-anca vasculitis icd-9 code process. Why #10; If the hyperthyroid disorder as a raging fire! Every time you can do to help replenish the symptoms of hyperthyroid that has not be taking thyroid are: shortness of breath and swelling of the gland or thyroidism affects women older than later Retinal vasculitis is used as a descriptive term to explain a conglomerate of typical clinical manifestations including perivascular sheathing or cuffing, vascular leakage and/or occlusion. It may be associated with signs of retinal ischemia, including cotton-wool spots and intra-retinal hemorrhage ANCA antibodies are associated with a different disease (ANCA vasculitis). In these 20-30% of patients with anti-GBM disease who also have ANCA antibodies in their blood, there is a much higher risk of the disease coming back or flaring again in the future. For this reason, testing for ANCA should be done in all patients with anti-GBM disease
ANCA-Positive Patients: The Influence of PR3 and MPO Antibodies (ICD-10). Diagno-sis in the ANCA-PR3-positive group was mostly Wegener's granulomatosis (72%). Other diagnoses in the ANCA-PR3- cohorts of PR3-ANCA positive patients with vasculitis [1, 13]. We included all PR3 positive patients irrespective of th - Glomerulonephritis due to antineutrophil cytoplasmic antibody (ANCA) positive vasculitis - Glomerulonephritis co-occurrent and due to antineutrophil cytoplasmic antibody positive vasculitis (disorder) ICD-10 Codes: N059 I776 + Granulomatosis with polyangiitis (disorder) Powered by X-Lab. This tool allows you to search SNOMED CT and is. Update on the management of ANCA-associated vasculitis. Jan. 11, 2019. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis comprises three different syndromes — granulomatosis with polyangiitis (GPA, also known as Wegener's granulomatosis); microscopic polyangiitis (MPA); and eosinophilic granulomatosis with polyangiitis (EGPA.
ICD-10: NO1.7 - nephritis rapidly progressive with diffuse crescentic glomerulonephritis Epidemiology. Rare, with an incidence of 0.5 - 1.6 cases per 1 million per year 79 year old woman with ANCA associated vasculitis and anti-GBM antibodies (CEN Case Rep 2020;9:42 the aetiology of ANCA-associated vasculitis, and infections may also be a trigger.13 The incidence of ANCA-associated vasculitis increases with age, and the peak age of onset is between 60 and 70 years.14 ANCA-associated vasculitis frequently involve multiple organ systems: most commonly the kidneys The p-ANCA test is useful for identifying systemic inflammation and vasculitis. In contrast, the MPO test performed by Cleveland HeartLab is useful for identifying cardiovascular risk. Sample Type The MPO test should be performed on an EDTA plasma sample. Commercial Insurance or Medicare Coverag In ANCA-associated vasculitis, including granulomatosis with polyangiitis (Wegener's, GPA), do increases in the ANCA tests predict disease relapse? A general and over-simplified answer is: no. This answer is based on the statistical analysis of large groups of patients followed prospectively in clinical trials
ANCA Vasculitides - Testing for anti-neutrophil cytoplasmic antibodies (P-ANCA and/or C-ANCA) has been found to be useful in establishing the diagnosis of suspected vascular diseases (e.g., crescentic glomerulonephritis, microscopic polyarteritis and Churg-Strauss syndrome), bowel disease (Crohn's Disease, ulcerative colitis, primary sclerosing cholangitis, and autoimmune hepatitis) as well as. PDF | Background: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a group of life-threatening autoimmune diseases. The... | Find, read and cite all the research you. Rituximab was effective in neurological involvement in 9/10 patients with vasculitis or cryoglobulinemia (90 %) (group 1) at 3 months and in 2/7 cases (29 %) without cryoglobulinemia and vasculitis (p = 0.03)
Antineutrophil cytoplasmic antibody (ANCA) is a specific autoantibody for ANCA-associated vasculitis (AAV). ANCA can be detected in up to 80-90% of AAV patients .The 2007 classification of ANCA-associated vasculitides and polyarteritis nodosa proposed by the European Medicine Agency (the 2017 EMA algorithm) and the 2012 revised International Chapel Hill Consensus Conference Nomenclature of. • The p-ANCA test (anti-MPO antibody test) is not the same as the MPO test performed by Cleveland HeartLab. The p-ANCA The following ICD-10 codes for MPO are listed as a convenience for the vasculitis as it is characterized by increased vascular inflammation H35.063 Retinal vasculitis, bilateral. H35.069 Retinal vasculitis, unspecified eye. I77.6 Arteritis, unspecified. L95 Vasculitis limited to skin, not elsewhere classified. L95.0 Livedoid vasculitis. L95.8 Other vasculitis limited to the skin. L95.9 Vasculitis limited to the skin, unspecified. M05.2 Rheumatoid vasculitis with rheumatoid. leukocytoclastic vasculitis, its clinical approach, differential diagnosis and treatment algorithm. Cutaneous vasculitis encompasses a wide spectrum of conditions of very different severity and urgency, from limited skin disease to severe systemic life-threatening vasculitis. This review will empower the reader with tool The survival rate, we found in ANCA-PR3 positive patients is lower then reported on large cohorts of PR3-ANCA positive patients with vasculitis [1, 13]. We included all PR3 positive patients irrespective of the diagnoses, while earlier studies had strict entry criteria and included only patients with a biopsy-proven diagnosis
When applied to at-risk populations, c-ANCA has a sensitivity of 85-90% and specificity of 90-95% in active systemic GPA. In organ-limited disease, the sensitivity decreases to 65-86%. p-ANCA is often positive in ulcerative colitis and Crohn's disease, and is also commonly positive in drug-induced skin vasculitis Approximately 90% of patients with PICG have circulating ANCA antibodies, leading to the systemic small vessel vasculitis such as granulomatosis with polyangiitis (GPA). Corticosteroids and cyclophosphamide are the first-line treatment, but infection is the most common cause of death of RPGN patients Vasculitic Neuropathy. Vasculitis is a systemic illness with inflammation in the blood vessels. The inflammation may lead to occlusion of blood vessels and subsequent ischemia in the organs and tissues. When the inflammation is in the blood vessels supplying peripheral nerves, patients may develop vasculitic neuropathy 2021 ICD-10-CM Diagnosis Code N05.9: Unspecified nephritic . Icd10data.com DA: 17 PA: 41 MOZ Rank: 58. Vasculitis, positive anca, with glomerulonephritis ICD-10-CM N05.9 is grouped within Diagnostic Related Group (s) (MS-DRG v38.0): 698 Other kidney and urinary tract diagnoses with mcc 699 Other kidney and urinary tract diagnoses with c Necrotizing vasculitis also called Systemic necrotizing vasculitus (SNV) is a category of vasculitis, comprising vasculitides that present with necrosis. ICD-10 uses the variant necrotizing vasculopathy. ICD-9, while classifying these conditions together,.
Central nervous system (CNS) vasculitis is inflammation of blood vessel walls in the brain or spine. (The brain and the spine make up the central nervous system.) CNS vasculitis often occurs in the following situations: Accompanied by other autoimmune diseases such as systemic lupus erythematosus, dermatomyositis and rarely, sarcoidosis and. The test for ANCA identifies 2 types of antibodies-cytoplasmic (cANCA), which are specific for PR3 and perinuclear (pANCA), which are specific for MPO. The presence of MPO is quite specific for MPA (diagnostic specificity approaches 95%); but, it is recommended that positive results obtained by EIA be confirmed by another testing method Systemic Vasculitis - TreatmentHowever, most vasculitis in general are treated with steroids (e.g methylprednisolone) because the underlying cause of the vasculitis is due to hyperactive immunological damage cytoplasmic antibody (ANCA) positive vasculitis identified best treatments depending on whether the goal is to induce remission or maintenance and depending on severity of the. . Two patients were double positive for MPO/PR3-ANCA. Of the 80 patients with MPA, 47 had ILD Vasculitis is an inflammatory destructive process affecting blood vessels. Pulmonary vasculitis may be secondary to other conditions or constitute a primary, and in most cases idiopathic, disorder. Underlying conditions in the secondary vasculitides are infectious diseases, connective tissue diseases, malignancies, and hypersensitivity disorders
Introduction. α 1-Antitrypsin deficiency (AATD) is a genetically determined condition that can affect different organs, leading to various clinical manifestations, including pulmonary emphysema, liver cirrhosis, cytoplasmic anti-neutrophil cytoplasmic antibody (c-ANCA)-positive vasculitis and the inflammatory skin disease panniculitis .The most common clinically relevant AATD alleles are Pi. . Almost all patients who develop giant cell arteritis are over the age of 50. GCA commonly causes headaches, joint pain, facial pain, fever, and difficulties with vision, and sometimes permanent visual loss in one or both eyes
c-ANCA & p-ANCA for Rheumatologic Disease. C-ANCA and p-ANCA are two tests used in the diagnosis and evaluation of rheumatologic diseases. These conditions often result from a dysfunction in the immune system, which triggers an attack on certain tissues in the body that it mistakes as foreign or invading microorganisms or poisons Microscopic polyangiitis (MPA) is an uncommon disease. It is the result of blood vessel inflammation ( vasculitis ), which can damage organ systems. The areas most commonly affected by MPA include the kidneys, lung, nerves, skin, and joints. MPA shares many common features with another form of vasculitis called granulomatosis with polyangiitis. Granulomatosis with Polyangiitis is a disease involving granulomatous inflammation, necrosis and vasculitis that most frequently targets the upper respiratory tract, lower respiratory tract, and kidneys. Although Granulomatosis with Polyangiitis can begin at any age, the average age of onset is about 40 years
Service Area must be determined. Includes. ANCA Screen with Reflex to ANCA Titer, Myeloperoxidase Antibody (MPO), Proteinase-3 Antibody. If ANCA Screen is positive, then C-ANCA Titer and/or P-ANCA Titer and/or atypical P-ANCA Titer will be performed at an additional charge (CPT code (s): 86021 for each titer performed). Methodology Pulmonary-renal syndrome is diffuse alveolar hemorrhage plus glomerulonephritis, often occurring simultaneously. Cause is almost always an autoimmune disorder. Diagnosis is by serologic tests and sometimes lung and renal biopsy. Treatment typically includes immunosuppression with corticosteroids and cytotoxic drugs
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease (AID) with the hallmarks of chronic inflammation within the blood vessels and the production of ANCAs directed against myeloperoxidase (MPO) and proteinase 3 (PR3) .AAV is classified into three different disease entities based on the characteristic histologic, serologic, and clinical features  Essential features. Rare, systemic, small to medium vessel granulomatous vasculitis ( Allergy 2013;68:261 ) Diagnosed clinically by the presence of. Asthma. Blood eosinophilia exceeding 1,500/mm 3. Evidence of vasculitis involving 2 or more organs. Renal manifestations occur in 45% of those with the diagnosis and include HBV-associated PAN patients are positive for active hepatitis B infection and can present in similar fashion to idiopathic generalized PAN . Microscopic PAN has ANCAs directed against myeloperoxidase (MPO) and involvement of small arterioles (microscopic polyangiitis [MPA]). This is now classified as ANCA-associated vasculitis Objective. To compare the rate of severe infections after the onset of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with the rate in the background population, and to identify predictors of severe infections among patients with AAV. Methods. The study cohort was 186 patients with AAV diagnosed from 1998 to 2010, consisting of all known cases in a defined population in.
Leukocytoclastic vasculitis, also called hypersensitivity vasculitis, describes inflammation of small blood vessels. The term leukocytoclastic refers to the debris of neutrophils (immune cells) within the blood vessel walls. The disease can be confined to the skin (cutaneous) or it can affect many different organs of the body such as the. Glomerulonephritis (GN) due to infective endocarditis (IE) is well documented, but most available data are based on old autopsy series. To update information, we now present the largest biopsy-based clinicopathologic series on IE-associated GN. The study group included 49 patients (male-to-female ratio of 3.5:1) with a mean age of 48 years. The most common presenting feature was acute kidney. ANA performed if ANCA positive to rule out false positive ANCA due to presence of ANA. Expected Turnaround Time. 10 - 12 days. (WG), particularly with active disease, and less frequently in other forms of necrotizing vasculitis Billing Code. 5011423. CPTCode. 83516 MPO; 83516 PR-3; 86255 ANCA; if reflexed, add 86256 ANCA titer. PDF ANCA-Associated Vasculitis Testing Test Bulletin. Notes. Specimens are screened for ANCA, MPO and PR-3. If the ANCA screen detects antibodies at a 1:20 dilution or greater, then a titer to end point will be added Vasculitis can cause problems in the central and peripheral nervous systems, where it affects the blood vessels that nourish the brain, spinal cord, and peripheral nerves. (The peripheral nervous system is the vast network of nerves that carry messages to and from the central nervous system to the body. ICD-9 Code: 782.61. ICD-10 Code: R23.1 Definition: Livedo reticularis is a painless, cyanotic mottling of the skin in a fishnet pattern. It may affect extremities or trunk and is exaggerated by cold exposure. It may be associated with autoimmune diseases, vasculitis, Raynaud's phenomenon, fibromyalgia, atheromatous disease, hyperviscosity syndrome, thrombotic conditions, and exposure to cold.